Background: Assessing the liver function provides valuable information to evaluate surgical risk and plan\naccordingly. Current studies focus on whole liver function evaluation. However, assessment of segmental liver\nfunction is equally important in the clinical practice. The purpose of this study was to investigate whether Gd-EOBDTPA-\nenhanced MRI can evaluate the liver function of each segment by using T1 mapping at 3 Tesla MRI.\nMethods: One hundred three patients were classified into one of 4 groups: a normal liver function (NLF) group (n= 38),\na liver cirrhosis with Child-Pugh A (LCA) group (n=33), a liver cirrhosis with Child-Pugh B (LCB) group (n= 21), and a liver\ncirrhosis with Child-Pugh C (LCC) group (n=11). All patients underwent Gd-EOB-DTPA-enhanced MRI scans. T1 relaxation\ntimes were measured on the liver superimposing T1 mapping images. Reduction rate (ââ??³%) of T1 relaxation time of the\nliver parenchyma were calculated.\nResults: After 20 min of Gd-EOB-DTPA enhancement, the T1 relaxation time of all liver segments in the LCC group were\ndifferent from those in all the other groups, and more liver segments from the LCB and LCA groups different from the\nNLF group (p< 0.05). For the LCB group, the areas under the receiver operating characteristic curves (AUCs) of different\nliver segments for hepatobiliary phase (HBP) were 0.654-0.904 on T1 relaxation time, and 0.709-0.905 on ââ??³%. For the LCC\ngroup, the AUCs of different liver segments for HBP were 0.842ââ?¬â??0.997 on T1 relaxation time, and 0.887ââ?¬â??0.990 on ââ??³%.\nConclusions: For LCB patients, segmental liver function evaluation is possible using Gd-EOB-DTPA-enhanced MRI T1\nmapping. For LCC patients, all liver segments can be used to evaluate liver function and both T1 relaxation time and the\nââ??³% of T1 relaxation time have good diagnostic performance.
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